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Discovery and development of MEDI7247, a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, for treating hematological cancers

Preclinical studies using TLR9 antagonists or genetic deletion have shown attenuation of neuroinflammation and improved neuronal survival in models of CNS injury and disease [130]

Nrf2 activation mitigates this process by attenuating intracellular ROS accumulation, thereby indirectly suppressing inflammatory signals such as NF-B 43

Adequate dietary protein and progressive resistance training remain the most evidence-supported approaches to maintain muscle protein synthesis during weight loss

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