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Caf-Au-Lait Macules Well-circumscribed, uniformly light to dark brown macules or patches that often range from 2 to 5 cm (in adults) Usually noted during infancy or early childhood Found in 1020% of the normal population but can serve as a marker of an underlying genodermatosis, especially when multiple Epidemiology In an individual, the number of caf-au-lait macules (CALMs) can vary from one to more than a dozen

In aging mice, which exhibit features of senescence as they age, DQ treatment significantly decreased senescence markers and senescence-associated inflammatory mediators in gum tissues, restoring them to levels observed in young, non-senescent gums