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where clinical endpoints are used (e.g., CIPN severity, skin lightening), findings are mixed and often context-specific

282 Moreover, IL-22Fc induces MTs in the liver, resulting in decreased hepatic ROS production, stress kinase activation, and inflammatory functions, leading to the amelioration of nonalcoholic steatohepatitis

Mitochondrial health is vital for maintaining energy levels, metabolic functions, and reducing oxidative stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Finan B., Yang B., Ottaway N., Smiley D.L., Ma T., Clemmensen C., Chabenne J., Zhang L., Habegger K.M., Fischer K., et al

However, despite their proven efficacy, challenges remain in long-term safety, adherence, and accessibility for adolescents