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Understanding the Herxheimer Reaction During Candida detox, some people experience a temporary worsening of symptoms known as the Herxheimer reaction or die-off. This occurs when Candida dies off rapidly, releasing toxins into the bloodstream, leading to symptoms like: Headaches Fatigue Nausea Skin breakouts Brain fog To manage the Herxheimer reaction: Start antifungal treatments slowly and gradually increase dosage