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Researchers believe that combining these effects may influence weight and metabolism in a different way compared to existing treatments

TRIUMPH-4: Obesity + Knee Osteoarthritis (Read out December 2025) Reported 28.7% mean weight loss at 12 mg over 68 weeks

Patients and clinicians should remain vigilant and monitor hormone levels regularly if both treatments are used concurrently, even in a research context

Today, these agents are frequently prescribed earlier in the disease course and maintained for extended periods

Glucagon-like peptide-1, or GLP-1, is a natural incretin hormone that is produced by the gut and helps the body to perform metabolism (breakdown and synthesis of chemical substances)