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The gut microbiome's role in GLP-1 regulation is an active area of research, with emerging evidence suggesting that microbial diversity and specific bacterial strains may influence incretin hormone secretion, but more human studies are needed to establish clinical significance

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Chronic constipation: current treatment options

These findings provide compelling evidence in support of the hypothesis that GLP-1 RAs inhibit glucagon secretion by stimulating the release of somatostatin, an effect that is independent of insulin and the secretory products of -cells

References Dwivedi, Divya, et al