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Through this mechanism, GLP-1RAs may reduce endothelial dysfunction and oxidative stress, both of which are key contributors to sepsis pathophysiology (57)

In this test, mice sensitized by a comparatively rigorous regime (the intradermal injection of adjuvant followed by the daily application of the test material, for 4 consecutive days, to tape-stripped skin) are challenged on one ear with the test compound and on the contralateral ear with vehicle alone

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This stabilization effect is particularly relevant in neurological autoimmune conditions where overactive microglia contribute to nerve damage