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The researchers defined 16 GLP-1RA treatment scenarios for GLP-1RA users by semi-annually reassigning their treatment status, conditional on their current use status, thereby emulating dynamic treatment strategies over time

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Affecting approximately 50% of patients with diabetes, DN is predominantly characterized by distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, often resulting in diabetic foot ulcers and lower-limb amputations

Stack-specific unknowns Combined GH elevation could raise the chance of GH-related effects like water retention, joint discomfort, or numbness/tingling if pushed high