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The official 16-week titration schedule should be followed

Of these, 377 records were excluded as they did not meet the inclusion criteria (e.g., wrong population, intervention, or study design)

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Evaluation of the effects of sodium-glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality in patients with chronic heart failure and a preserved ejection fraction: rationale for and design of the EMPEROR-Preserved trial