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The two most studied incretin hormones are GLP-1 and GIP, produced in response to nutrients entering the gastrointestinal tract, mediated by G-protein-coupled receptors on -cells [18]

53 mmol/mol (7.0%) for those on agents with hypoglycaemia risk

In a meta-analysis including data from 4887 participants treated with tirzepatide and 2328 control participants, an HR of 0.80 (95% CI 0.57, 1.11) was calculated for four-point MACE (MACE-4), 0.90 (95% CI 0.50, 1.61) for cardiovascular death and 0.80 (95% CI 0.51, 1.25) for all-cause mortality [95]

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