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Through advances in surgery, radioactive iodine therapy, and newer treatments like targeted therapies and immunotherapy, many thyroid cancer patients can expect long-term survival and a good quality of life

This creates a troubling cycle: poor sleep increases inflammation, which then makes sleep even worse

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Combining the two pharmacological options is safe and does not induce hypoglycemia

Interestingly, while oxyntomodulin-bound GLP-1R displayed a more similar TMD conformation to that bound to GLP-1 in the static cryo-EM structure, the effect of mutagenesis was more divergent, with numerous mutations differentially impacting oxyntomodulin affinity and/or signalling data relative to GLP-1 (Supplemental Figures 9-10, Supplemental Table 2)