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Funding The study was supported by the Experimental Laboratory of the Department of Intensive Care, Universit Libre de Bruxelles (ULB), Belgium

Abstract It is well established that the involvement of reactive species in the pathophysiology of several neurological diseases, including phenylketonuria (PKU), a metabolic genetic disorder biochemically characterized by elevated levels of phenylalanine (Phe)

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Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy

Importantly, benefits extend beyond weight reduction including anti-inflammatory effects, lipid profile improvement, and favorable cardiac remodeling