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2.4 Statistical analysis 2.4.1 MR analysis Before MR analysis, we harmonized exposure and outcome data by aligning effect alleles to the forward strand, discarding palindromic variants

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As the half-life of retatrutide is 6 days, once weekly administration was sufficient with as expected gastrointestinal disturbance being the most common side effect and occurring in 63% of those on retatrutide, 60% on dulaglutide, and 54% of the placebo cohort [63]