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Some practitioners recommend 4-6 week breaks every 6-12 months to assess natural function and prevent potential receptor downregulation, though long-term studies show sustained efficacy

With TriHex technology, this product uses a proprietary peptide blend to help clear away old, damaged collagen and encourage the growth of new, healthy collagen for smoother, more youthful-looking skin, says Saami Khalifian, MD, a board-certified dermatologist in San Diego