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[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Jang JP, Jung HJ, Han JM, Jung N, Kim Y, Kwon HJ, et al

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Understanding Tirzepatide and Semaglutide: Mechanisms of Action Semaglutide and another medication are both classified as GLP-1 receptor agonists, yet they exhibit notable differences in their mechanisms of action

Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population