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Its primary function is G-actin sequestration TB4 binds monomeric actin with nanomolar affinity, regulates the polymerizable actin pool, and indirectly governs cytoskeletal dynamics during cell migration, wound healing and inflammatory response

Simultaneously, mitochondria release Smac/Diablo, HtrA2, and Arts, which promote apoptosis by inhibiting the X-linked inhibitor of apoptosis protein (XIAP) (Tower, 2015)

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