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The function of VDR depends not only on ligand binding with 1,25-dihydroxyVitamin D but also on its dynamic interactions with coactivators (e.g., SRC-1, DRIP205/MED1), epigenetic enzymes (e.g., HDACs, LSD1, PRMT5), and corepressor/de-repressor complexes (e.g., NCoR/SMRT), which are recruited and reorganized in a ligand-inducible manner to mediate precise gene regulation [113,114,115]

REFERENCES 1.NCD Risk Factor Collaboration (NCD-RisC), author Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants

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