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It upregulates the Nrf2 (Nuclear factor erythroid 2-related factor 2) pathway, a critical cellular defense mechanism

Hypoglycaemia risk is generally low with GLP-1 agonists alone but may be elevated when combined with insulin or sulfonylureas, particularly in patients with poor nutritional status or irregular eating patterns

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However, their use requires careful monitoring, with potential side effects including urinary tract infections, dehydration, and rare cases of diabetic ketoacidosis or bone fractures