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Muscle preservation usually requires adequate protein, resistance training, enough total nutrition, hydration, and medical monitoring when needed

In a 26-week study, orforglipron demonstrated a significant dose-dependent effect on weight loss, with weight reduction ranging from 8.6% to 12.6% across various dosages, compared to only 2.0% in the placebo group

Weaning off tirzepatide requires the same patience and monitoring as the initial dose escalation phase

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For patients with persistent reflux symptoms despite 8 weeks of PPI therapy or those with alarm features, referral to gastroenterology for upper endoscopy may be warranted, consistent with American College of Gastroenterology guidelines