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Advanced in vitro models To bypass the limitations of 2D cultures, advanced in vitro culture systems have been developed, including the use of 3D organized structures, known as organoids, and kidney microphysiological systems (MPS) that can recreate fluidic characteristics found in vivo (Fig

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Different clinical symptoms reported in individual patients with 5-oxoprolinase deficiency are renal stone formation, enterocolitis, mental retardation, neonatal hypoglycemia, microcytic anemia and microcephaly [4045]

SiesH.1991aOxidative stress: from basic research to clinical application.American Journal of Medicine.9131380002-9343 65