A comprehensive meta-analysis of 37 randomized controlled trials involving 2,292 participants found that L-Carnitine supplementation significantly decreased body weight by 1.21 kg, body mass index (BMI) by 0.24 kg/m, and fat mass by 2.08 kg compared to placebo
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doi: 10.3390/ijms23020739 Summary Keywords metabolic reprogramming, glucagon-like peptide-1 receptor agonists, heart failure, cardiovascular system, diabetes Citation Wang X, Qi M, Yang L, Yang L, Wang X, Zhang F, Cui Y, Wang D, Wang Y and Lv W (2025) GLP-1 receptor agonists synergistic effects of metabolic reprogramming and cardioprotection
GLP-1 activates K ATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection
It enhances metabolic performance, boosts circulation, and accelerates muscle recovery making it ideal for individuals with liver conditions or those with active lifestyles
