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The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice

GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes Nature Reviews Nephrology volume 13, pages605628 (2017) GLP-1(glucagon-like peptide 1) GIP(glucose-dependent insulinotropic polypeptide)

Because several donor atoms participate simultaneously, the complex is generally more stable than one formed by a single ligand interaction

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