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GLP-1RAs attenuate apoptosis in cardiomyocytes induced by hyperglycemia via inhibiting receptor of advanced glycation end products (RAGE) receptor [82]

Blood sugar management may need adjustment during the break period

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Interestingly, in a two year follow up study which was conducted 12 months after the subjects stopped receiving exenatide the researchers found that participants previously exposed to exenatide demonstrated a significant improvement (based on a blind assessment) in their motor features when compared to the control subjects involved in the study