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Liu Y, Zhang J, Li L, Yin G, Zhang J, Zheng S, Cheung H, Wu N, Lu N, Mao X, Yang L, Zhang J, Zhang L, Seth S, Chen H, Song X, Liu K, Xie Y, Zhou L, Zhao C, Han N, Chen W, Zhang S, Chen L, Cai W, Li L, Shen M, Xu N, Cheng S, Yang H, Lee JJ, Correa A, Fujimoto J, Behrens C, Chow CW, William WN, Heymach JV, Hong WK, Swisher S , Wistuba II, Wang J, Lin D, Liu X, Futreal PA, Gao Y

This is a genuine structural failure that goes beyond what biology alone can bridge

Glutathione therapeutics As an increase in GSH appears to be a ubiquitous response to oxidants and electrophiles and some diseases appear to be exacerbated by decreasing GSH, increasing GSH by using delivery of permeable esters (Levy et al., 1993) or increasing the availability of cysteine using the non-toxic precursor N-acetylcysteine (Thor et al., 1979) have been proposed

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This leads to the dislocation of apical and basolateral transporters (e.g., Na/K-ATPase) resulting in a leaky epithelium