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Although the FAERS database aids in detecting rare adverse events via spontaneous reporting, its propensity to overestimate unexpected adverse events linked to new therapies makes it inappropriate for comparative analysis of adverse event frequencies among pharmaceuticals

Peer review Peer review information Nature Communications thanks Chao Xu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Enteroviral infection: the forgotten link to amyotrophic lateral sclerosis