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Additionally, as you age, the internal pathways that convert precursors into usable NAD+ become less efficient

For example, those who follow vegan or vegetarian diets or are over the age of 60 may need supplementation (Pawlak, 2014

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Due to the mediating position of the folate cycle between the two adjacent cycles, a folic acid deficiency has widespread consequences: the production of SAM falls, as does that of BH4 and the associated neurotransmitters

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