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That nuclear translocation under metabolic stress is documented in the published literature: a peer-reviewed study in Cell Metabolism demonstrating that MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress in an AMPK-dependent manner describes the exact mechanism

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Pumpkin seed extract provides phytosterols and antioxidant support.* Lycopene and tomato powder add carotenoids that concentrate in prostate tissue and support long-term cell protection.*

A greater ETD in terms of weight loss over 12 months was observed in females as compared to males (-1.63% vs