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doi: 10.1016/j.fitote.2014.08.007

The gap between plausible mechanism and demonstrated cosmetic benefit is not a formality

All randomized participants received at least one dose of the study drug and were included in both the full and safety analysis populations [1]

However, for most people who continue treatment, side effects improve substantially with time, proper dose titration, and implementation of dietary and lifestyle strategies that work with the medications mechanisms