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The interactions within the TVS, immune cells, and ongoing neurogenic or neuroinflammatory responses play significant roles in migraine pathophysiology, potentially leading to the establishment of chronic maladaptive pain

doi: 10.3389/fendo.2024.1309118

This is characterized by a pronounced accumulation of skin-dwelling V4 T cells producing IL-17 and an escalated secretion of cytokines associated with Th17, namely IL-17A, IL-17F, and IL-22 (77)

It also examines the genes involved in melatonin production and suggests lifehacks to increase its production

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