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Reviewer 1 Building off of the last major Results comments, the Tam used in these studies influences cells that express ERT2 but likely has direct and indirect effects on other cells as well (as the authors know, since they have a nice ER discussion paragraph)

Across trials, results are generally supportive, though study designs vary in dosage, formulation, duration, and participant demographics

It is important to inform treating clinicians of all substances being used, including peptides, to enable safe and accurate assessment