In summer 2023, its likely that Mounjaro (known as tirzepatide generically) will be officially approved by the FDA for weight loss as well (it seems to be one more large study on safety and efficacy away)
Whilst Wegovy provides pharmacological support for weight loss, optimal outcomes are achieved when combined with reduced calorie intake and increased physical activity
1,4 About POMC, PCSK1, and LEPR deficiencies Rare autosomal recessive disorders 2 Lead to hyperphagia and early-onset, severe obesity, mainly due to genetic variants in the MCR4 pathway 2 Can be difficult to diagnose based solely on clinical manifestations, so genetic testing is required to confirm a diagnosis 1,5 Learn if IMCIVREE may be appropriate for your patients with POMC, PCSK1, or LEPR deficiency
FDA inspectors found that, as well as repackaging GLP-1s, GenoGenix compounded medicines including 5-amino-1-methylquinolinium iodide (5-Amino-1MQ) and nicotinamide adenine dinucleotide (NAD+)
166 ablated ghrelin in ob/ob mice with leptin deficiency, which failed to rescue the obese phenotype of hyperphagia, indicating that ghrelin was not the root cause of obesity
