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Side Effects of Spironolactone Common Side Effects Dizziness and headache Gastrointestinal upset such as nausea or diarrhea Hyperkalemia leading to muscle weakness or palpitations Hormonal effects including gynecomastia and menstrual irregularities Serious Adverse Effects Severe hyperkalemia with potential for life-threatening arrhythmias Renal dysfunction and elevated creatinine levels Endocrine-related side effects such as impotence or breast tenderness Drug Interactions Interaction with ACE inhibitors and ARBs Combined use significantly increases the risk of hyperkalemia and requires close monitoring
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3 No reference is made to the serum value or a danger of overdosing, unlike for instance in case of a vitamin D or A deficiency
A recent clinical study further confirmed that NSW disrupts 24-hour rhythms of PER2, PER3, BMAL1, and ESR2 in PBMCs, impairs the inverse correlation between PER2 and BMAL1, and alters PER1 and ESR1 expression patterns, highlighting a misalignment in the peripheral circadian network associated with NSW schedules 212
