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But for most people reading this, tirzepatide is the only practical option today and the evidence for starting now rather than waiting is stronger than the 6-percentage-point efficacy difference might suggest

The ATTAIN-1 trial enrolled 3,127 participants and compared three doses of orforglipron (6, 12 and 36 mg) with placebo over 72 weeks

Before and after treatment, a kidney biopsy is obtained for single-cell sequencing, and multiparametric kidney MRI is performed

These medications tend to share a similar side effect profile

These cardiovascular benefits are particularly important because obesity is a major risk factor for heart disease, stroke, and related conditions