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We plan for keeping it off from day one whether that means gradually tapering, staying at a maintenance dose, or transitioning off with new habits locked in

LDL-C is causal, not just associated with atherosclerosis

If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below

Limbutara, K., Chou, C

two minutes), meaning it gets degraded quickly by digestive enzymes