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These include: Lymph tissue in the wall of the appendix that has become enlarged Hardened stool, parasites, or other growths Irritation and ulcers in the gastrointestinal tract Abdominal injury or trauma Foreign objects, such as pins, stones, or bullets Air pollution has also been linked to an increased risk of appendicitis

Therapeutic significance of necroptosis in IRI-AKI Several novel inhibitors of necroptosis are effective in experimental models of renal IRI, making them promising targets for the treatment of AKI

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