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ALA is a universal antioxidant because it dissolves in both water-based fluids and fatty tissues, allowing it to move throughout the body in a way that many other antioxidants cannot
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These factors may contribute to the strongly immunosuppressive tumor microenvironment (TME) of PCa and poor response to immune checkpoint blockade (ICB) 9
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The high dose of cyanocobalamin is generally well-tolerated due to the vitamins water-soluble nature and efficient excretion of excess amounts
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