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ATB-352 shows promising analgesic effects with less gastrointestinal toxicity compared to ketorolac, but its long-term safety and human applicability require further clinical evaluation

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however, the generally accepted model is that after ligand binding to LRP1, the ligandLRP1 complex is taken up into early endosomes ( +/+ HepG2 cells, ICC data show that HPX moves into two populations of endosomes (Figure 4)