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J Clin Endocrinol Metab 2008

Protective effect of a coffee preparation (Nescafe pure R ) against carbon tetrachloride-induced liver fibrosis in rats

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11 This can lead to long-term lung damage and other issues

If you can deliver the same drug only into the cells where you want PPAR activation (the metabolically-active cells expressing GLP-1R or GIPR) and leave the rest of the bodys PPARs untouched, you have a chance of breaking the side-effect ceiling that has limited the entire class for two decades