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Pyruvate then re-enters mitochondria for the next round of carboxylation by PC

On GLP-1, the appetite suppression makes the higher carb days easier to control because you are less likely to overeat even with more carbohydrates available

In parallel, glycine, another major component of collagen, is synthesized from serine, which is derived from the glycolytic intermediate 3-phosphoglycerate via the enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH), and subsequently converted by serine hydroxymethyltransferase 1/2 (SHMT1/2) [17, 18]

doi: 10.1016/j.molmet.2019.04.003 156 ZingalesVDistefanoARaffaeleMZanghiABarbagalloIVanellaL

The true payers are the patients, the federal and state governments to a certain extent, and the employers