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The samples were incubated on ice and centrifuged to separate the serum, which was then collected, transferred to clean tubes, and stored until further experimentation took place [2]

Severe niacin deficiency, known as pellagra, has been historically associated with poverty and consumption of a diet predominantly based on corn, which is low in bioavailable niacin (25, 26)

B6 is a rate limiting cofactor in the synthesis of several neurotransmitters such as dopamine, serotonin, -aminobutyric acid (GABA), noradrenaline and the hormone melatonin (1)

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The article also discusses their specific mechanisms and potential as future therapeutic treatments.