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A Paradigm Shift in Chronic Disease Treatment GLP-1 receptor agonists represent a fundamental shift in treating chronic illness by simultaneously targeting the three pillars fueling modern diseases: insulin resistance, obesity, and inflammation

Additionally, people who are more sensitive to changes in gastric motility, and those on higher medication doses, may be more prone

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Statistical analysis Results were analyzed as a full factorial least squares model using JMP version 10 (SAS, Cary, NC)

Here, using a metabolic-scale CRISPR activation screen integrated with transcriptomic and metabolomic analyses, we identify L-2-hydroxyglutarate dehydrogenase (L2HGDH) as a potent antagonist of ferroptosis in HCC