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P-glycoprotein (P-gp) substrate drugs : In vitro, saponins and phenolic compounds from Tribulus terrestris has been shown to inhibit P-gp activity

Dose selection should weigh both curves

Evans JM, Ogston SA, Emslie-Stnith A, Morris AD: Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin

as a continuous variable), female gender (1.48), Asian (1.25) or African origin (1.29), diabetes (1.27), obesity (1.31), hypothyroidism (1.38), chronic liver (1.24) or kidney disease (1.25), alcohol consumption (1.22), exercise (1.23), the use of antiarrhythmic agents (1.31), calcium channel blockers (1.36) or statins, primarily at high doses (1.38) [411]

Characterisation of enzymatically prepared biosurfactant