Patients interested in the Phase 3 programme should check ClinicalTrials.gov or the EU Clinical Trials Register for current trial identifiers, eligibility criteria, and participating sites, as the programme name and trial details should be verified against these authoritative registers
In the Phase 2 obesity trial, heart-rate increases were dose-dependent, peaked around 24 weeks and then declined afterwards
What matters, however, is what management can forecast with confidence and what it cannot
Early integration of chemistry, manufacturing, and controls considerations into translational planning is therefore essential to avoid late-stage attrition
We have previously proposed that the mode of action of liraglutide may involve inhibition of upper gastrointestinal motility resulting in a greater transit time of the luminal content, thus allowing more time for passive and transporter-mediated active absorption of bile acids in the small intestine (20,25) (Figure 2)
