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The N-hexanoic (C-terminal) and 6-aminohexanoic amide (N-terminal) modifications introduced during the lead-optimization phase of the Harding laboratorys Ang IV-analog program were specifically designed to increase hydrophobicity, decrease hydrogen bonding, and improve metabolic stability against the proteases that degrade native angiotensin IV

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Likewise, in dose and application regimens as described before heparin (Belupo, Croatia), warfarin (Martefarin (Orion Pharma, Finland)), L-NAME (Sigma, USA) and L-arginine (Sigma, USA) dissolved in saline were used as well [1,14,15]

To view a copy of this licence, visit About this article Cite this article Chang, D., Kong, F., Jiang, W