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Summary DPP-4 inhibitors, while not the most potent drugs at lowering A1c, nevertheless are very attractive to use in the treatment of patients with T2DM as they are safe drugs that do not have many side effects

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By activating GLP-1 receptors in the brain, pancreas, and digestive tract, semaglutide reduces appetite, slows gastric emptying, and improves insulin sensitivity

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