Beyond Metabolism: Broader Health Benefits of GLP-1s The influence of GLP-1s extends far beyond their direct impact on metabolism and inflammation, touching upon various other critical aspects of health and longevity
Studies of metformin, DPP-4 inhibitors, SGLT2 inhibitors, GLP-1 RAs, and pioglitazone in individuals who have undergone solid organ transplantation have demonstrated effectiveness and safety but are limited by small sample sizes, short follow-up, and risk of bias due to retrospective, single-center, or single-arm prospective designs (287)
So, the first thing is to point out that there will be room for a lot of different approaches
Schneiders W, Reinstorf A, Pompe W, Grass R, Biewener A, Holch M, et al
The study protocol was approved by the Independent Bioethics Committee for Scientific Research at the Medical University of Gdansk (NKBBN/354 201/2017) and registered in the ClinicalTrials.gov Registry (NCT05120011)