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Further comparative biochemical and pharmacological investigations are necessary before asserting that DHK-Cu merits the same recognition as its more established equivalents [2]

The pathobiology of vascular dementia

Likewise, the suppressor oncogene p53 is capable of suppressing the activity of the IGF-1R promoter as well as lowering the endogenous levels of IGF-1R mRNA (Werner et al, 2000)

Fragasso G (2023) The concept of heart failure with preserved ejection fraction: time for a critical reappraisal

Alterations in energy metabolism in cardiovascular diseases often involve systemic pathophysiological changes across multiple systems, while the key energy metabolic targets (AMPK, SIRT) exhibit functional variances in different tissues, suggesting the need for in-depth mechanistic exploration using tissue-specific animal models and expanding clinical research in the future