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Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation

Abbreviations GLP-1: Glucagon-like peptide 1 GIP: Glucose-dependent insulinotropic polypeptide GLP-1R: Glucagon-like peptide 1 receptor GIPR: Glucose-dependent insulinotropic polypeptide receptor ASCVD: Atherosclerotic cardiovascular disease HF: Heart failure HFpEF: Heart failure with preserved ejection fraction HFrEF: Heart failure with reduced ejection fraction T2DM: Type 2 diabetes mellitus EF: Ejection fraction LVEF: Left ventricular ejection fraction LVEDV: Left ventricular end-diastolic volume LVESV: Left ventricular end-systolic volume LVSV: Left ventricular stroke volume CO: Cardiac output CI: Cardiac index BSA: Body surface area LVIDs: Left ventricular internal diameter in systole LVIDd: Left ventricular internal diameter in diastole LVFS: Left ventricular fractional shortening LVAWTs: The thickness of the left ventricular anterior wall in systole LVAWTd: The thickness of the left ventricular anterior wall in diastole LVPWTs: The thickness of the left ventricular posterior wall in systole LVPWTd: The thickness of the left ventricular posterior wall in diastole LV: Left ventricular mass RWT: Relative wall thickness LVRi: Left ventricular remodelling index AngII: Angiotensin II Veh: Vehiculum Lira: Liraglutide TZP: Tirzepatide ECG: Electrocardiography References Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emerson SS, Kahn SE, et al

This leads to reduced calorie intake and consistent, healthy weight loss when combined with physician supervision and lifestyle guidance