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Treatment with the two highest KBP-089 doses (1.25 and 2.5 g/kg) as well as their combinations with liraglutide resulted in a significant reduction in food efficiency compared with vehicle

8 When APAP is administered at therapeutic doses under normal physiological conditions, the remaining 510% of the drug is metabolized in hepatocytes by cytochrome P450 enzymes such as CYP2E1 and CYP1A2 through phase I enzymatic reactions, resulting in the generation of the toxic reactive metabolite NAPQI (Fig

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