Disproportionality Analysis Among all the 137583 PTs involving 26 SOC categories, significant SOCs related to tirzepatide which met at least one of the four algorithms were Injury, poisoning and procedural complications (SOC:10022117, n = 39065, ROR = 2.63), General disorders and administration site conditions (SOC:10018065, n = 34930, ROR = 1.62), Gastrointestinal disorders (SOC: 10017947, n = 26395, ROR = 2.66), and Metabolism and nutrition disorders (SOC:10027433, n = 4551, ROR = 1.77) ( Table S3 )
A lighter or leaner body receives more exposure per kilogram and may show a different balance of appetite, heart-rate, and lean-mass effects
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[DOI] [PubMed] [Google Scholar] 76.Potential side effects to GLP-1 agonists: understanding their safety and tolerability